Effect of onychomycosis and treatment on patient-reported quality-of-life outcomes: A systematic review
| Autor: | Charlene Rae, Cameron F Leveille, Khizar Abid, Leah Algu, Rakhshan Kamran, Claire R. Stewart, Shari R. Lipner |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antifungal Agents Itraconazole Administration Topical Dermatology Disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Onychomycosis Amorolfine medicine Humans Patient Reported Outcome Measures Intensive care medicine Efinaconazole Ciclopirox business.industry medicine.disease Nails 030220 oncology & carcinogenesis Nail fungus Quality of Life Terbinafine Female business medicine.drug |
| Zdroj: | Journal of the American Academy of Dermatology. 85:1227-1239 |
| ISSN: | 0190-9622 |
| Popis: | Background Onychomycosis is the most common nail disorder, often causing physical, emotional, and aesthetic consequences. The effect of both the condition itself and treatment on quality of life has not been well studied. Objective The objectives of this study were to systematically review the available literature describing the effect of onychomycosis and treatment on quality of life. Methods We performed a search of the onychomycosis literature published before April 13, 2020. Articles were included in the review if primary data were presented, patient-reported outcome measures were used, and onychomycosis was specifically examined. Results Thirty studies were included in the final analysis. Poorest quality-of-life scores were associated with women and fingernail involvement. Quality-of-life scores improved from baseline with all treatment types; there were greater improvements reported with oral treatments compared with topical ones. Conclusions This review affirms that onychomycosis significantly influences quality of life, warranting effective treatment. All treatments resulted in quality-of-life improvements; however, studies on oral and topical therapies were of higher quality than those evaluating devices. Increased efforts are needed to understand the effect of the disease and therapy as assessed by validated, nail-specific outcome measures that accurately assess patients' cosmetic, physical, and social difficulties. |
| Databáze: | OpenAIRE |
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