Evaluation of Factors Associated With Fracture and Loss of Bone Mineral Density Within 1 Year After Liver Transplantation
| Autor: | Ana Marcella Rivas, Ann E. Kearns, Colleen T. Ball, Shon Meek, Liu Yang, Ejigayehu G. Abate, Myrian Vinan Vega |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Liver transplantation Logistic regression End Stage Liver Disease 03 medical and health sciences Liver disease Fractures Bone 0302 clinical medicine Endocrinology Model for End-Stage Liver Disease Bone Density Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Dual-energy X-ray absorptiometry Retrospective Studies Bone mineral medicine.diagnostic_test business.industry Retrospective cohort study General Medicine Odds ratio medicine.disease Liver Transplantation business |
| Zdroj: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 27(5) |
| ISSN: | 1530-891X |
| Popis: | OBJECTIVE Orthotopic liver transplant recipients are at high risk of fragility fractures both in pre-liver transplant (pre-LT) and in the immediate posttransplant (post-LT) period. The aims of this study were to identify risk factors associated with post-LT fracture and identify factors that contribute to changes in bone mineral density (BMD) in post-LT as they relate to the risk of fracture in the immediate post-LT period. METHODS We conducted a retrospective cohort study of first-time LT recipients who had BMD testing within 2-year pre-LT and 1-year post-LT. We assessed factors associated with immediate post-LT fracture using logistic regression models and linear regression models. RESULTS New fractures occurred in 41/286 (14.3%) of LT recipients during the first year following LT. In multivariate analysis, we noted an increased odds of fracture for patients with prior history of fracture (P < .001), patients who were older (P = .03), patients with higher end-stage liver disease score (P = .03), and patients with lower BMD. After adjustment for multiple testing, only a history of prior fracture was statistically significant. CONCLUSION Our study demonstrated that prior fracture at any site was associated with developing a new fracture in the first year post-LT. |
| Databáze: | OpenAIRE |
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