Association Between Preoperative US, Elastography Features and Prognostic Factors of Papillary Thyroid Cancer With BRAF
| Autor: | Jun-Mei Xu, Yong-Jun Chen, Yuan-Yuan Dang, Man Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty elastography Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology Papillary thyroid cancer 03 medical and health sciences Endocrinology 0302 clinical medicine medicine thyroid cancer Prospective cohort study Halo sign Thyroid cancer Original Research lcsh:RC648-665 medicine.diagnostic_test Receiver operating characteristic business.industry ultrasound Neck dissection Odds ratio medicine.disease 030104 developmental biology Elastography Radiology prognosis medicine.symptom acoustic radiation force impulse business |
| Zdroj: | Frontiers in Endocrinology, Vol 10 (2020) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | Purpose: To investigate the value of US and elastography for predicting prognostic factors of papillary thyroid cancer (PTC) in the positive BRAFV600E Mutation group.Materials and Methods: A total of 116 BRAFV600E Mutation patients with PTCs were enrolled in this prospective study, who were preoperatively evaluated by US, US elasticity imaging (EI), and Virtual Touch tissue imaging (VTI) and Virtual Touch tissue quantification (VTQ) of acoustic radiation force impulse (ARFI) imaging. Multivariate logistic regression analysis was performed to assess 23 independent variables for predicting prognostic factors. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve analysis.Results: Forty-two (36.2%) of 116 PTC patients with BRAFV600E Mutation had central lymph node metastasis (LNM). Nine (7.8%) and fifty-six (48.3%) had lateral LNM and extra-thyroidal extension (ETE), respectively. In multivariate logistic regression analyses, rich internal flow [odds ratio [OR]: 6.66] was the best predictor for central LNM, followed by male sex (OR: 4.22), halo sign absence (OR: 2.78) (all P < 0.05). VTQ ratio (OR: 1.57) was the only predictor for lateral LNM (P = 0.02). Rich internal flow (OR: 6.33) was the strongest predictor for ETE, followed by male sex (OR: 3.29), halo sign absence (OR: 2.90), and VTQ ratio (OR: 1.63) (all P < 0.05).Conclusion: VTQ ratio on ARFI imaging, rich internal flow and halo sign absence on US are the predicting prognostic factors in PTC patients with BRAFV600E Mutation. The specificities were significantly increased by combining ARFI imaging and US features, which has a potential to avoid unnecessary therapeutic neck dissection in the high-risk PTC patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|