A Multivariate Analysis of the Risk of Cytomegalovirus Infection in Heart Transplant Recipients
| Autor: | Robert W. Stewart, Martin C. McHenry, Thomas F. Keys, Margaret J. Gorensek, Marlene Goormastic |
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| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Statistics as Topic Congenital cytomegalovirus infection Cytomegalovirus Antibodies Viral Serology Postoperative Complications Adrenal Cortex Hormones Risk Factors Betaherpesvirinae Internal medicine medicine Humans Immunology and Allergy Prospective Studies Risk factor Immunosuppression Therapy Heart transplantation Leukopenia biology business.industry virus diseases Immunosuppression biology.organism_classification medicine.disease Tissue Donors Transplantation Infectious Diseases Cytomegalovirus Infections Immunology Heart Transplantation Female medicine.symptom business |
| Zdroj: | Journal of Infectious Diseases. 157:515-522 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/157.3.515 |
| Popis: | Thirty-four consecutive heart transplant recipients were studied over a two-year period for evidence of cytomegalovirus (CMV) infection. Twenty-three episodes of CMV infection were identified; 19 of these occurred within 120 d after transplantation and were statistically analyzed. Fifteen potential risk factors were evaluated, including the following: pretransplant CMV serological status of donor and recipient; recipient's age, sex, race, and cardiac disease; number and type of blood products transfused; type and intensity of immunosuppression; occurrence of rejection; and leukopenia. The Cox proportional hazards model identified both greater than average steroid dosage and positive recipient CMV serology as significant risk factors for CMV infection (P = .014 and .048, respectively). In a separate analysis, however, only greater than average steroid dosage was associated with clinically significant CMV infection (P = .005). |
| Databáze: | OpenAIRE |
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