Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia
| Autor: | José Fernández Piqueras, Francisco J. Quintero-Gutierrez, M. Dolores Saiz-González, Jerónimo Saiz-Ruiz, Carolina Fernandez-Ramos, Montserrat Diaz-Hernandez, M. Mercedes Perez-Rodriguez, Enrique Baca-García, Carlota Botillo-Martin, Concepcion Vaquero Lorenzo, Jose L. Gonzalez de Rivera, Jose de Leon |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Risk Psychosis medicine.medical_specialty Genotype 5-HT2A receptor Gene Dosage Biology Polymorphism (computer science) Internal medicine mental disorders medicine Humans Receptor Serotonin 5-HT2A Allele Allele frequency Biological Psychiatry Alleles Pharmacology Polymorphism Genetic Reverse Transcriptase Polymerase Chain Reaction DNA medicine.disease Endocrinology Schizophrenia Spain Case-Control Studies Cochran–Armitage test for trend Female |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 30(6) |
| ISSN: | 0278-5846 |
| Popis: | Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele frequencies in 188 schizophrenia patients and 440 healthy controls. There were significant differences in the distribution of the three genotypes (TT, TC and CC) and in the allele frequencies in controls and schizophrenics. The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C). |
| Databáze: | OpenAIRE |
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