Oral ciprofloxacin or trimethoprim reduces bacteriuria after flexible cystoscopy
| Autor: | Teresea Lennon, K.E. Orr, David E. Neal, John Masters, John N. S. Matthews, David A. Merrilees, Wendy Robson, Mark I. Johnson |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Bacteriuria Urology Anti-Infective Agents Urinary Placebo-controlled study Administration Oral Placebo Trimethoprim law.invention Double-Blind Method Randomized controlled trial Ciprofloxacin Risk Factors law Internal medicine Humans Medicine Prospective Studies Antibiotic prophylaxis Antibacterial agent business.industry Cystoscopy Antibiotic Prophylaxis bacterial infections and mycoses medicine.disease Surgery Treatment Outcome business medicine.drug |
| Zdroj: | BJU International. 100:826-829 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2007.07093.x |
| Popis: | OBJECTIVE To report a large prospective, pragmatic, double-blind randomized controlled trial to determine whether oral prophylactic antibiotics reduce the risk of bacteriuria after flexible cystoscopy (FC), as up to 10% of patients develop urinary infection afterwards, with significant morbidity and costs for health services. PATIENTS AND METHODS In all, 2481 patients were recruited into a three-arm placebo controlled trial and 2083 completed it. Patients were randomly assigned to one of three treatments; (i) placebo; (ii) one oral dose of trimethoprim (200 mg); or (iii) one oral dose of ciprofloxacin (500 mg), each administered 1 h before a FC under local anaesthetic. A mid-stream urine specimen was taken before and 5 days after FC; significant bacteriuria was defined as a pure growth of >105 colony-forming units/mL. RESULTS The rate of bacteriuria after FC was reduced from 9% in the placebo group to 5% and 3% in patients receiving trimethoprim and ciprofloxacin prophylaxis, respectively. When rates of bacteriuria before FC were considered the odds of developing bacteriuria after FC relative to baseline were 5, 2 and 0.5 for placebo, trimethoprim and ciprofloxacin, respectively. CONCLUSION This large trial shows clearly that one dose of oral ciprofloxacin significantly reduces bacteriuria after FC. |
| Databáze: | OpenAIRE |
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