Lack of relationship between glycemic control and bone mineral density in type 2 diabetes mellitus
Autor: | Milton César Foss, D M S L Cutrim, F. A. Pereira, F. J. A. de Paula |
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Rok vydání: | 2007 |
Předmět: |
Male
medicine.medical_specialty Deoxypyridinoline Bone markers Ocean Engineering Type 2 diabetes Bone remodeling chemistry.chemical_compound Absorptiometry Photon Diabetes mellitus Glycemic control Bone Density Internal medicine Bone mineral density Humans Medicine lcsh:QH301-705.5 Femoral neck Bone mineral lcsh:R5-920 biology business.industry Type 2 Diabetes Mellitus Insulin-like growth factor I Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Diabetes Mellitus Type 2 lcsh:Biology (General) chemistry Case-Control Studies Hyperglycemia Osteocalcin biology.protein Osteoporosis Female Bone Remodeling Glycated hemoglobin lcsh:Medicine (General) business Biomarkers |
Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 40, Issue: 2, Pages: 221-227, Published: 05 DEC 2006 Brazilian Journal of Medical and Biological Research v.40 n.2 2007 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 40, Iss 2, Pp 221-227 (2007) |
ISSN: | 1414-431X |
Popis: | We assessed the effect of chronic hyperglycemia on bone mineral density (BMD) and bone remodeling in patients with type 2 diabetes mellitus. We investigated 42 patients with type 2 diabetes under stable control for at least 1 year, 22 of them with good metabolic control (GMC: mean age = 48.8 +/- 1.5 years, 11 females) and 20 with poor metabolic control (PMC: mean age = 50.2 +/- 1.2 years, 8 females), and 24 normal control individuals (CG: mean age = 46.5 +/- 1.1 years, 14 females). We determined BMD in the femoral neck and at the L2-L4 level (DEXA) and serum levels of glucose, total glycated hemoglobin (HbA1), total and ionic calcium, phosphorus, alkaline phosphatase, follicle-stimulating hormone, intact parathyroid hormone (iPTH), 25-hydroxyvitamin D (25-OH-D), insulin-like growth factor I (IGFI), osteocalcin, procollagen type I C propeptide, as well as urinary levels of deoxypyridinoline and creatinine. HbA1 levels were significantly higher in PMC patients (12.5 +/- 0.6 vs 7.45 +/- 0.2% for GMC and 6.3 +/- 0.9% for CG; P < 0.05). There was no difference in 25-OH-D, iPTH or IGFI levels between the three groups. BMD values at L2-L4 (CG = 1.068 +/- 0.02 vs GMC = 1.170 +/- 0.03 vs PMC = 1.084 +/- 0.02 g/cm(2)) and in the femoral neck (CG = 0.898 +/- 0.03 vs GMC = 0.929 +/- 0.03 vs PMC = 0.914 +/- 0.03 g/cm(2)) were similar for all groups. PMC presented significantly lower osteocalcin levels than the other two groups, whereas no significant difference in urinary deoxypyridine was observed between groups. The present results demonstrate that hyperglycemia is not associated with increased bone resorption in type 2 diabetes mellitus and that BMD is not altered in type 2 diabetes mellitus. |
Databáze: | OpenAIRE |
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