Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies
| Autor: | Thiago Gomes Heck, Matias Nunes Frizzo, Alberto A. Rasia-Filho, Mirna Stela Ludwig, Paulo Ivo Homem de Bittencourt |
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| Rok vydání: | 2020 |
| Předmět: |
Immunology & Inflammation
medicine.drug_class Pneumonia Viral Inflammation Disease Molecular Bases of Health & Disease Virus Anti-inflammatory Betacoronavirus critically ill patient heat shock response Interferon Chiroptera Heat shock protein Infecções por coronavirus Animals Humans Medicine Heat shock Pandemics Review Articles Heat-Shock Proteins Diabetes & Metabolic Disorders fever SARS-CoV-2 business.industry COVID-19 General Medicine medicine.disease Cardiovascular System & Vascular Biology inflammation Immunology Translational Science Interferons medicine.symptom Coronavirus Infections business Cytokine storm Resposta ao choque térmico Heat-Shock Response medicine.drug |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Clinical Science Clinical Science (London, England : 1979) |
| ISSN: | 1470-8736 0143-5221 |
| Popis: | The major risk factors to fatal outcome in COVID-19 patients, i.e., elderliness and pre-existing metabolic and cardiovascular diseases (CVD), share in common the characteristic of being chronic degenerative diseases of inflammatory nature associated with defective heat shock response (HSR). The molecular components of the HSR, the principal metabolic pathway leading to the physiological resolution of inflammation, is an anti-inflammatory biochemical pathway that involves molecular chaperones of the heat shock protein (HSP) family during homeostasis-threatening stressful situations (e.g., thermal, oxidative and metabolic stresses). The entry of SARS coronaviruses in target cells, on the other hand, aggravates the already-jeopardized HSR of this specific group of patients. In addition, cellular counterattack against virus involves interferon (IFN)-mediated inflammatory responses. Therefore, individuals with impaired HSR cannot resolve virus-induced inflammatory burst physiologically, being susceptible to exacerbated forms of inflammation, which leads to a fatal “cytokine storm”. Interestingly, some species of bats that are natural reservoirs of zoonotic viruses, including SARS-CoV-2, possess an IFN-based antiviral inflammatory response perpetually activated but do not show any sign of disease or cytokine storm. This is possible because bats present a constitutive HSR that is by far (hundreds of times) more intense and rapid than that of human, being associated with a high core temperature. Similarly in humans, fever is a physiological inducer of HSR while antipyretics, which block the initial phase of inflammation, impair the resolution phase of inflammation through the HSR. These findings offer a rationale for the reevaluation of patient care and fever reduction in SARS, including COVID-19. |
| Databáze: | OpenAIRE |
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