Association Between Antipsychotic-induced Elevation of Liver Enzymes and Weight Gain
| Autor: | Elisabeth M. Weiss, Martina Hummer, Ursula Eder-Ischia, W. Wolfgang Fleischhacker, Maria A. Rettenbacher, Monika Edlinger, Georg Kemmler, Alex Hofer, Ivo Graziadei, Susanne Baumgartner, Regina Huber |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Weight Gain Blood cell Liver Function Tests Internal medicine medicine Humans Pharmacology (medical) Aspartate Aminotransferases Prospective Studies Antipsychotic Prospective cohort study Aged Chemotherapy medicine.diagnostic_test business.industry Alanine Transaminase gamma-Glutamyltransferase Middle Aged medicine.disease Psychiatry and Mental health medicine.anatomical_structure Endocrinology Liver Schizophrenia Female Drug Monitoring medicine.symptom business Liver function tests Body mass index Weight gain Biomarkers Antipsychotic Agents |
| Zdroj: | Journal of Clinical Psychopharmacology. 26:500-503 |
| ISSN: | 0271-0749 |
| DOI: | 10.1097/01.jcp.0000236654.85791.ae |
| Popis: | We conducted a prospective, open study in schizophrenia patients treated with second-generation antipsychotics in order to investigate the risk for elevation of liver enzymes and its correlation to antipsychotic-induced weight gain. Body mass index, serum transaminases, plasma serum levels of the antipsychotic used, and blood cell counts were measured weekly during the first 6 weeks of treatment and monthly thereafter. A considerable proportion of subjects showed an increase beyond normal levels of at least one of the measured transaminases. In all but one case, the elevation of liver enzymes was transient. We found a statistically significant correlation between weight gain and liver enzyme elevation. The group of patients that had gained at least 7% of the baseline body weight showed significantly higher increases of transaminases as compared with those who had gained less than 7% weight. We conclude that antipsychotic-induced elevation of liver enzymes is mostly transient and could be associated with weight gain. |
| Databáze: | OpenAIRE |
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