Critical tissue oxygen tension defines tissue oxygen debt in the isolated hindlimb of the pig during progressive ischemia
| Autor: | E. W. Scholten, van der Kleij Aj, P. J. Klopper, Stefan O.P. Hofer, P. F. Gründeman |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Extracorporeal Circulation Swine Partial Pressure Ischemia chemistry.chemical_element Hindlimb Critical Care and Intensive Care Medicine Oxygen Oxygen Consumption Internal medicine Medicine Animals Muscle Skeletal business.industry Extracorporeal circulation Oxygen transport Hemodynamics Skeletal muscle Anatomy Blood flow medicine.disease Oxygen tension medicine.anatomical_structure chemistry Cardiology Disease Progression Regression Analysis Female Blood Gas Analysis business |
| Zdroj: | Critical care medicine. 23(5) |
| ISSN: | 0090-3493 |
| Popis: | Objective: To determine a critical skeletal muscle oxygen tension (PO 2 ) value below which a tissue oxygen debt develops. Design: Descriptive study of oxygen transport values in relation to skeletal muscle PO 2 throughout progressive ischemia by means of arterial blood flow reductions in an isolated hindlimb model in the pig. Setting: Surgical Research department of the University of Amsterdam. Subjects: Six female Yorkshire pigs weighing 26 to 35 kg (average 33). Interventions: Controlled blood flow to the isolated hindlimb was achieved by means of extracorporeal circulation. The hindlimb was studied during progressive flow reduction. Measurements and Main Results: Oxygen delivery (DO 2 ) and oxygen consumption were calculated as the product of extracorporeal blood flow and, respectively, arterial oxygen content and arterial-venous oxygen content difference. In this fashion, an oxygen supply dependency could be determined in all animals. A critical DO 2 value was determined below which a tissue oxygen debt developed. Skeletal muscle PO 2 was measured continuously, using a Clark-type polarographic oxygen sensor. Combining the critical DO 2 value with the corresponding skeletal muscle PO 2 value resulted in a critical skeletal muscle PO 2 value of 15.2±0.4 torr (2.0±0.1 kPa). Conclusion: In this pig model, a critical skeletal muscle PO 1 value could be determined below which a tissue oxygen debt presumably developed |
| Databáze: | OpenAIRE |
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