Clinicopathological study of chronic hepatitis induced by alcohol with or without hepatitis G virus
| Autor: | Makoto Sawada, Koshi Shimanaka, Mutsumi Tsuchishima, Hiromu Kawahara, Sachio Urashima, Shujiro Takase, Yasuhiro Ueshima, Mikihiro Tsutsumi |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Alcoholic liver disease medicine.medical_specialty Pathology media_common.quotation_subject Medicine (miscellaneous) Toxicology Gastroenterology Virus Flaviviridae Internal medicine medicine Humans Aspartate Aminotransferases media_common Aged Hepatitis Chronic Hepatitis medicine.diagnostic_test biology Ethanol business.industry Hepatitis Alcoholic virus diseases Alanine Transaminase gamma-Glutamyltransferase Abstinence Hepatitis B Middle Aged medicine.disease biology.organism_classification digestive system diseases Psychiatry and Mental health Liver biopsy RNA Viral Viral hepatitis business |
| Zdroj: | Alcoholism, clinical and experimental research. 23 |
| ISSN: | 0145-6008 |
| Popis: | The concept of chronic hepatitis induced by alcohol (AL-CH) has not been widely accepted, because AL-CH may be due to non-A-E hepatitis virus in heavy drinkers. Recently, hepatitis G virus (HGV) was identified as a positive-strand RNA virus related to members of the Flaviviridae family. In this study, we determined serum HGV in patients with AL-CH and analyzed the clinicopathological changes after abstinence to evaluate whether AL-CH is caused by alcohol or not. Serum samples were obtained from 16 patients with AL-CH who had neither hepatitis B nor C virus. The diagnosis was confirmed histologically. In eight patients, liver biopsy was performed twice, within 3 days and 4 to 8 weeks after abstinence. The NS3 region of the HGV genome was detected using an reverse transcriptase-polymerase chain reaction method. Serum levels of AST, ALT and gamma-glutamyltranspeptidase were measured once a week sequentially after admission. Serum HGV-RNA was detected in only one patient with AL-CH (6.3%). In all patients, including one patient with HGV, serum levels of AST, ALT and gamma-glutamyltranspeptidase clearly decreased to normal levels after abstinence. Inflammatory activity in the periportal area of patients with actively drinking decreased or disappeared after abstinence for 4 to 8 weeks. These results suggest that HGV may not play an important role for development of AL-CH, and that AL-CH may be caused by alcohol itself, although a more larger number of patients with AL-CH are needed to obtain definitive conclusions. |
| Databáze: | OpenAIRE |
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