Proto-oncogene abnormalities and their relationship to tumorigenicity in some human glioblastomas
| Autor: | James D. Hatton, Patricia Y. Kelley, Hoi Sang U, Jin Y. Shew |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Cellular differentiation
Mice Nude Chromosome Disorders Biology medicine.disease_cause Proto-Oncogene Mas Mice Neuroblastoma Nude mouse Epidermal growth factor Proto-Oncogenes Gene expression Gene duplication Tumor Cells Cultured medicine Animals Humans Neuroectodermal tumor Chromosome Aberrations Oncogene Eye Neoplasms Gene Amplification Retinoblastoma Glioma medicine.disease biology.organism_classification ErbB Receptors Cancer research Carcinogenesis Cell Division Neoplasm Transplantation |
| Zdroj: | Journal of Neurosurgery. 71:83-90 |
| ISSN: | 0022-3085 |
| Popis: | ✓ Human glioblastomas are highly malignant intracranial tumors, some of which demonstrate amplification of the epidermal growth factor-receptor (EGF-R) gene. Overexpression of this gene is seen in the majority of primary tumors; however, the role of the EGF-R gene in glial tumorigenesis is unknown. The authors explored the relationship between EGF-R gene expression and glioblastoma cell growth in vitro and in vivo and found that the level of EGF-R gene expression did not correlate with tumor cell growth either in soft agar or in the nude mouse. This suggests that the EGF-R gene is not involved in effecting direct growth stimulation in glial oncogenesis. Tumorigenesis involves differentiation arrest; therefore, the expression of several proto-oncogenes in neuroectodermal tumors was investigated to evaluate the potential involvement of the EGF-R gene in glial differentiation. A nonoverlapping expression of the N-myc and EGF-R genes was found in neuronal-derived and glial-derived tumors, respectively. This suggests that the EGF-R gene may be involved in differentiation or its arrest in glia. |
| Databáze: | OpenAIRE |
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