An immunological syndrome featuring transverse myelitis, Evans syndrome and pulmonary infiltrates after unrelated bone marrow transplant in a patient with severe aplastic anemia
| Autor: | Eileen Scigliano, Steven M. Fruchtman, Shambavi Richard, Luis Isola, D Skerrett, Vesna Najfeld |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Evans syndrome medicine.medical_treatment Graft vs Host Disease Myelitis Transverse myelitis hemic and lymphatic diseases medicine Humans Pulmonary Eosinophilia Aplastic anemia Lung Bone Marrow Transplantation Purpura Thrombocytopenic Idiopathic Transplantation Cytopenia business.industry Coombs-positive hemolytic anemia Anemia Aplastic Immunosuppression Syndrome Hematology medicine.disease medicine.anatomical_structure Anemia Hemolytic Autoimmune Bone marrow business |
| Zdroj: | Bone Marrow Transplantation. 26:1225-1228 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/sj.bmt.1702677 |
| Popis: | A patient with severe aplastic anemia underwent a matched unrelated bone marrow transplant, following which he developed a complex autoimmune syndrome. This featured transverse myelitis, immune mediated Coombs positive hemolytic anemia and immune thrombocytopenia (Evans syndrome), pulmonary infiltrates, eosinophilia, muscle pains and cramps and lichenoid dermatitis all of which may represent manifestations of graft-versus-host disease as they showed response to immunosuppression. Thus, although immune-mediated cytopenias after an allogeneic bone marrow transplant are rare, they should be considered as a possible cause of cytopenia in post-transplant patients. |
| Databáze: | OpenAIRE |
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