Thyroid hormone metabolism and the developing human lung
| Autor: | Kerry Richard, Ellen Kaptein, Theo J. Visser, Robert Hume, Michael W.H. Coughtrie, Emma L. Stanley |
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| Přispěvatelé: | Internal Medicine |
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Thyroid Hormones Deiodinase DIO2 Iodide Peroxidase Thyroid hormone receptor beta Fetal Organ Maturity Thyroid peroxidase Pregnancy Internal medicine Medicine Humans Lung Arylsulfatases Thyroid hormone receptor Triiodothyronine biology business.industry Sulfates Thyroid Endocrinology medicine.anatomical_structure Pediatrics Perinatology and Child Health biology.protein Female Sulfotransferases business Developmental Biology Hormone |
| Zdroj: | ResearcherID Biology of the Neonate, 80(1), 18-21. Karger |
| ISSN: | 1421-9727 1661-7800 0006-3126 |
| DOI: | 10.1159/000047172 |
| Popis: | Thyroid hormones are involved in the regulation of fetal lung development, and maturation is accelerated in animal models by antepartum exposure to raised concentrations of the receptor-active thyroid hormone triiodothyronine and glucocorticoids. It is essential that the nature of the regulation of the spatial and temporal metabolism of iodothyronines in the human fetus and infant is known before effective therapies can be developed to modify human lung maturation. Thyroid hormone bioavailability to the human fetus is regulated in part by enzymatic deiodination and reversible sulfation of iodothyronines, with contributions from other factors such as fetomaternal and fetoamniotic hormone transfers, fetal thyroid gland production, and the activities of plasma membrane transporters mediating uptake of iodothyronines from plasma into tissues. |
| Databáze: | OpenAIRE |
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