Severe and non-severe asthma in the community: A large electronic database analysis

Autor: David Segev, Shabtai Varsano, David Shitrit
Rok vydání: 2016
Předmět:
Pulmonary and Respiratory Medicine
Adult
Male
Pediatrics
medicine.medical_specialty
Databases
Factual
Cross-sectional study
Population
macromolecular substances
Omalizumab
Comorbidity
Severity of Illness Index
03 medical and health sciences
Pulmonary Disease
Chronic Obstructive
Young Adult
0302 clinical medicine
Risk Factors
Severity of illness
medicine
Prevalence
Electronic Health Records
Humans
030212 general & internal medicine
Anti-Asthmatic Agents
Treatment Failure
Israel
education
Asthma
Aged
Retrospective Studies
education.field_of_study
business.industry
musculoskeletal
neural
and ocular physiology
Retrospective cohort study
Middle Aged
medicine.disease
Clinical trial
Hospitalization
Cross-Sectional Studies
nervous system
030228 respiratory system
Emergency medicine
Female
business
Emergency Service
Hospital
medicine.drug
Zdroj: Respiratory medicine. 123
ISSN: 1532-3064
Popis: Background A large electronic database analysis was conducted in a community of 351,799 people, ages 20–70 years to determine the prevalence and clinical characteristics of severe asthma, according to 2014 international guidelines and healthcare utilization. Methods Severe asthmatics were grouped into controlled severe-asthma and uncontrolled severe-asthma and additional subgroups of uncontrolled severe asthma on the basis of medications dispensed. Non-asthmatic population at the same ages served as controls. Results A total of 19,991 (5.68%) were diagnosed as asthmatic, of which 4.65% had severe asthma. Of these, one-third was uncontrolled severe-asthma. Controlled severe-asthma group was similar to non-severe asthma and non-asthmatics in the rate of emergency room visits (21.5%, 22%, and 20%, respectively) and to all cause hospitalizations (7.4%, 7.4%, and 6.4%, respectively). Uncontrolled severe-asthmatics had significantly more hospitalizations (RR = 2.9) than controlled severe-asthmatics. Only 19.2% of uncontrolled-severe asthmatics had IgE testing and 3.6% were dispensed omalizumab. Conclusions The prevalence of severe asthma is slightly less than 5% of all asthmatics. Controlling severe asthma is crucial to reducing healthcare utilization. A simple electronic database analysis, based on dispensed medications, can help healthcare providers identify subgroups of uncontrolled severe asthmatics that require focused efforts. Clinical trial registration : NCT01961258. Ethics Committee approval : 032/2013C.
Databáze: OpenAIRE
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