Paternal age, body mass index, and semen volume are associated with chromosomal aberrations-related miscarriages in couples that underwent treatment by assisted reproductive technology
| Autor: | Zhiyuan Wang, Xiaocong Liu, Linli Hu, Shanjun Dai, Yihong Guo, Qingling Yang, Wenbin Niu, Jiawei Xu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Reproductive Techniques Assisted paternal age medicine.medical_treatment Semen Single-nucleotide polymorphism Polymorphism Single Nucleotide chromosome karyotype Body Mass Index Miscarriage Young Adult Pregnancy Risk Factors miscarried fetus medicine Humans body mass index (BMI) semen parameters Retrospective Studies Chromosome Aberrations Assisted reproductive technology Obstetrics business.industry Cell Biology Odds ratio Middle Aged medicine.disease Confidence interval Abortion Spontaneous Logistic Models Female Trisomy business Body mass index Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.103151 |
| Popis: | We investigated the effects of paternal characteristics, including age, body mass index (BMI), and semen parameters on chromosomal aberration-related miscarriages in couples that underwent treatment with assisted reproductive technology (ART). Single nucleotide polymorphism (SNP) array analysis showed chromosomal aberrations in 60.2% (557/925) of miscarried fetuses, including trisomy in 73.1% (407/557) of cases. There were higher chromosomal aberration rates in fetuses for men aged 20-24 years and ≥30 years compared with controls. After adjusting for age and BMI of the female partners, and the BMI and semen parameters of the males, there was no statistically significant effect of paternal age ≥30 years on the risk of chromosomal aberrations-related miscarriages. However, the odds of chromosomal abnormality-related miscarriage were 148% higher for the youngest fathers (age: 20-24 years) than fathers aged 25-29 years [adjusted odds ratio (OR): 2.48, 95% confidence interval (CI): 1.03-5.96; P=0.042]. Furthermore, high male BMI (adjusted OR: 1.56, 95% CI: 1.14-2.14; P=0.005) and low semen volume (adjusted OR: 2.09, 95% CI: 1.06-4.11; P=0.034) were associated with increased risk of chromosomal aberration-related miscarriages. These findings demonstrate that very young paternal age, high BMI, and low semen volume are associated with increased risk of chromosomal aberration-related miscarriages in couples undergoing ART treatment. |
| Databáze: | OpenAIRE |
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