Phytochemical analysis and biological evaluation of Lagochilus species from Uzbekistan
| Autor: | Thomas Rosenau, Davlat Kh Akramov, Markus Bacher, Lutfun Nahar, Stefan Böhmdorfer, Nilufar Z. Mamadalieva, Satyajit D. Sarker, Antje Potthast, Gokhan Zengin |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
RM S1 Lagochilus Iridoid Traditional medicine 010405 organic chemistry medicine.drug_class Lagochilin Biology biology.organism_classification Daucosterol 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Phytochemical Glucoside Genus medicine Lamiaceae Agronomy and Crop Science 010606 plant biology & botany |
| Zdroj: | Industrial Crops and Products. 154:112715 |
| ISSN: | 0926-6690 |
| DOI: | 10.1016/j.indcrop.2020.112715 |
| Popis: | The species of the genus Lagochilus (Lamiaceae) are widespread in Central, South-Central, and Eastern Asia. Some of these species are used for their medicinal and therapeutic effects, in particular as hemostatic, anti-inflammatory and anti-epileptic agents. A new iridoid, glucoside 7- cinnamoyllamalbide, along with known compounds lagochilin, 5-hydroxy-7,4′-dimethoxyflavone, daucosterol, β-sitosterol, 8-acetylharpagide were isolated from L. gypsaceus. The high-performance thin-layer chromatography (HPTLC) method was used to determine the chemical fingerprints of 7 different Lagochilus species (L. acutilobus, L. gypsaceus, L. inebrians, L. olgae, L. proskorjakovii, L. setulosus, L. vvedenskyi). Among the tested species, lagochilin content was highest in the endemic species L. inebrians collected from the Djizzakh region of Uzbekistan. In free radical scavenging and reducing power assays, L. inebrans and L. vvedenskyi exhibited the strongest abilities. Regarding cholinesterases, amylase and glucosidase inhibition abilities of the tested samples, 5-hydroxy-7,4′-dimethoxyflavone was the most active compound. |
| Databáze: | OpenAIRE |
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