Neuroimaging correlates of persistent fatigue in older adults: A secondary analysis from the Multidomain Alzheimer Preventive Trial (MAPT) trial
| Autor: | Ali Bouyahia, Jérémy Raffin, Mapt, Matteo Cesari, Sandra De Breucker, Marie Chupin, Philipe de Souto Barreto, Jean-François Mangin, Emmanuelle Gourieux, Yves Rolland, Davide Angioni, Kelly Virecoulon Giudici, Clara Fischer, Bruno Vellas |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty brain health Population Neuroimaging tau Proteins white matter hyperintensity volume sub-cortical volumes 03 medical and health sciences 0302 clinical medicine Preventive trial Alzheimer Disease Secondary analysis Gériatrie - gérontologie medicine Humans education Fatigue older adults Aged education.field_of_study 030214 geriatrics medicine.diagnostic_test business.industry Brain Mean age Magnetic resonance imaging cortical thickness Magnetic Resonance Imaging Frailty phenotype Psychiatry and Mental health Cross-Sectional Studies White matter hyperintensity Female Geriatrics and Gerontology Pshychiatric Mental Health business Gerontology 030217 neurology & neurosurgery Psychiatrie |
| Zdroj: | Aging & mental health |
| Popis: | Objectives: Fatigue has been suggested as a marker of biological aging. It seems plausible that this symptom might be associated with changes in brain health. The objective of this study was to examine the associations between persistent fatigue and neuroimaging correlates in a non-disease-specific population of community-dwelling older adults. Methods: We performed a cross-sectional analysis using data from The Multidomain Alzheimer Preventive Trial (MAPT). We included 458 subjects. Persistent fatigue was defined as meeting exhaustion criterion of Fried frailty phenotype in two consecutive clinical visits six months apart between study baseline and one year. Brain imaging correlates, assessed by magnetic resonance imaging (MRI), were the outcomes. The associations between persistent fatigue and brain correlates were explored using mixed model linear regressions with random effect at the center level. Results: The mean age of the participants was 74.8 ± 4 years old, and 63% of the subjects were women. Forty-seven participants (10%) exhibited a persistent fatigue profile. People with persistent fatigue were older compared to subjects without persistent fatigue (76.2 years ± 4.3 vs.74.7 ± 3.9 p = 0.009). Persistent fatigue was associated with higher white matter hyperintensity volume in the fully adjusted analysis. We did not find any cross-sectional association between persistent fatigue and sub-cortical volumes and global and regional cortical thickness. Conclusion: Persistent fatigue was cross-sectionnally associated with higher white matter hyperintensity volume in older adults. Further longitudinal studies, using an assessment tool specifically designed and validated for measuring fatigue, are needed to confirm our findings. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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