Early assessment of renal resistance index after kidney transplant can help predict long-term renal function
| Autor: | Giovanni Santarsia, Angelo Saracino, V. Gaudiano, Angela Latorraca |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Urology Renal function Kidney chemistry.chemical_compound Medicine Humans Retrospective Studies Transplantation Univariate analysis Creatinine Proteinuria business.industry Graft Survival Age Factors Ultrasonography Doppler Middle Aged medicine.disease Prognosis Kidney Transplantation Tissue Donors Surgery Blood pressure chemistry Nephrology Multivariate Analysis Trough level Female Vascular Resistance Hemodialysis medicine.symptom business Kidney disease |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 21(10) |
| ISSN: | 0931-0509 |
| Popis: | BACKGROUND Color Doppler ultrasonography of intrarenal arterial resistance index (RI), performed early after kidney transplant, has proven to reliably predict short-term allograft function. The aim of this study was to assess whether it could also predict long-term renal function. METHODS We retrospectively analysed 76 kidney transplant patients who underwent RI assessment within 1 month after the transplant, subdivided into two groups according to RI values, lower (group A) or higher (group B) than its median value (0.635). RESULTS Compared with group A subjects, the patients of group B were older at the time of transplant (42 +/- 9 vs 35 +/- 8 years; P = 0.001), the donor age was also older (41 +/- 16 vs 33 +/- 13 years; P = 0.02) and had a slightly higher proteinuria (0.54 +/- 0.5 vs 0.32 +/- 0.2 g/24 h; P = 0.02). Serum creatinine, ciclosporin or tacrolimus trough level, arterial blood pressure, number of human leukocyte antigen (HLA) mismatches, anti-hypertensive medications and incidence of delayed graft function were not significantly different between the two groups. By univariate analysis, RI turned out to directly correlate with the recipient age, donor age and daily proteinuria (P = 0.007, P = 0.0007 and P = 0.02, respectively). Multivariate analysis showed that only donor and recipient age maintained their independent predictive value on RI. Kaplan-Meier analysis, considering a serum creatinine increase >50% as the endpoint of the study, showed a statistically significant different graft survival in the two groups (log-rank test = 5.489; P = 0.01). The univariate relative risk of deterioration of graft function among patients with higher RI was 3.77. Proteinuria and recipient age increased the risk as well. CONCLUSIONS Our data seem to suggest that early determination of RI can help predict long-term graft function in kidney transplant recipients. |
| Databáze: | OpenAIRE |
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