Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention?
| Autor: | Huseyin Sancar Bozkurt, Eamonn Martin Quigley |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
biology business.industry Colorectal cancer Bifidobacterium MAIT cells Cancer colorectal cancer Gut flora biology.organism_classification medicine.disease digestive system Pathogenesis 03 medical and health sciences fluids and secretions 030104 developmental biology 0302 clinical medicine Immune system Immunology Medicine business Homeostasis 030215 immunology Hormone |
| Zdroj: | Gastrointestinal Disorders Volume 1 Issue 2 Pages 22-272 |
| ISSN: | 2624-5647 |
| DOI: | 10.3390/gidisord1020022 |
| Popis: | Colorectal cancer is the most preventable form of cancer worldwide. The pathogenesis of colorectal cancer includes gut inflammation, genetic and microbial composition factors. İmpairment of the gut microbiota has been associated with development of colorectal cancer. The genus Bifidobacterium is an important component of the commensal gut microbiota. Bifidobacteria are considered to have important roles in multiple homeostatic functions: immunologic, hormonal and metabolic. Mucosal-associated invariant T cells (MAIT) are components of the immune system involved in protection against infectious pathogens and regulate the pathogenesis of various inflammatory diseases and, potentially, colorectal cancer. Engagement between Bifidobacterium and MAIT cells could exert a beneficial effect on colorectal cancer prevention and treatment. |
| Databáze: | OpenAIRE |
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