Synthesis and biological activity of anticoccidial agents: 5,6-Diarylimidazo[2,1-b][1,3]thiazoles

Autor:	Susan Meitz, John Mathew, Penny Sue Leavitt, Anne Gurnett, Donald Thompson, Paul A. Liberator, Michael H. Fisher, Tesfaye Biftu, Dennis M. Schmatz, Andrew Scribner, Matthew J. Wyvratt, Chris Brown
Rok vydání:	2008
Předmět:	Stereochemistry Clinical Biochemistry Substituent Pharmaceutical Science Biochemistry Chemical synthesis chemistry.chemical_compound In vivo Drug Discovery Cyclic GMP-Dependent Protein Kinases Animals Combinatorial Chemistry Techniques Potency Protein Kinase Inhibitors Molecular Biology chemistry.chemical_classification Molecular Structure Organic Chemistry Imidazoles Biological activity In vitro Thiazoles Enzyme chemistry Coccidiostats Molecular Medicine Eimeria Amine gas treating
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:5263-5267
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2008.08.063
Popis:	Novel 5,6-diarylimidazo[2,1-b][1,3]thiazoles bearing an amine substituent at the imidazothiazole 2-position have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 10.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f97a9f9374860ab441b140794bd85f https://doi.org/10.1016/j.bmcl.2008.08.063 Zobrazit plný text záznamu Full Text from ScienceDirect