Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke
| Autor: | Chao-Zhong Peng, Li Li, Yanbao Hu, Xinhui Tian, Zhongmei Zou, Gang Ding, Hong Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Pharmaceutical Science Asteraceae Article Analytical Chemistry HeLa lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery Ic50 values Organic chemistry Humans Physical and Theoretical Chemistry Dichrocephala benthamii Dichrocephala benthamii C. B. Clarke Isovalerate Dichrocephala biology Phenylpropionates absolute configuration determination Organic Chemistry sinapyl alcohol derivatives biology.organism_classification Lipids chemistry Sinapyl alcohol Solubility Chemistry (miscellaneous) Molecular Medicine cytotoxicity HeLa Cells |
| Zdroj: | Molecules Volume 18 Issue 2 Pages 1720-1727 Molecules, Vol 18, Iss 2, Pp 1720-1727 (2013) |
| ISSN: | 1420-3049 |
| Popis: | Four new sinapyl alcohol derivatives dichrocephols A–D (compounds 1–4) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 1–3 showed moderate cytotoxity against HeLa cells, with IC50 values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|