Amniotic fluid‐derived mesenchymal stem cell products combined with microneedling for acne scars: A split‐face clinical, histological, and histometric study

Autor:	Noha H. Moftah, Ghada A Nasif, Sameh W. Ameen, Maha H Ragaie, Michel R. Ibrahim, Moetaz El-Domyati
Rok vydání:	2019
Předmět:	medicine.medical_specialty Amniotic fluid Treatment regimen business.industry Mesenchymal stem cell Epidermal thickness Scars Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine medicine.symptom Acne scars business
Zdroj:	Journal of Cosmetic Dermatology. 18:1300-1306
ISSN:	1473-2165 1473-2130
DOI:	10.1111/jocd.13039
Popis:	BACKGROUND Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars. OBJECTIVE To compare efficacy of amniotic fluid-derived mesenchymal stem cell-conditioned media (AF-MSC-CM) and microneedling vs microneedling alone in management of atrophic acne scars. METHODS Ten cases with atrophic postacne scars received five sessions of microneedling, with 2-week interval on both sides of the face. Then, AF-MSC-CM was topically applied to right side of the face after microneedling. Clinical examination with histopathological and computerized histometric analysis was done 1 month after the sessions. RESULTS There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF-MSC-CM) vs left side of face (dermaroller; P
Databáze:	OpenAIRE
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