Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel
| Autor: | Noam Harel, Avi Peretz, Nadav Sorek, Danielle Miller, Naama M. Kopelman, Sharon Amit, Yonat Shemer-Avni, Omer Tirosh, Amit Huppert, Diana Roif-Kaminsky, Katia Koelle, Shiraz Gefen-Halevi, Moran Meir, Avraham Shaag, Adi Stern, Olesya Vorontsov, Dana G. Wolf, Michael A. Martin, Talia Kustin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Epidemiology viruses Basic Reproduction Number General Physics and Astronomy Genome law.invention 0302 clinical medicine Communicable Diseases Imported law Pandemic Israel Child lcsh:Science Phylogeny Aged 80 and over Multidisciplinary Phylogenetic tree Viral Epidemiology Middle Aged Phylogenetics Transmission (mechanics) Psychological Distance Child Preschool RNA Viral Female Viral spread Coronavirus Infections Adult Adolescent Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Secondary infection Science Pneumonia Viral Genome Viral Biology Article Virus General Biochemistry Genetics and Molecular Biology Betacoronavirus Young Adult 03 medical and health sciences Humans Pandemics Aged Base Sequence SARS-CoV-2 Sequence Analysis RNA Infant Newborn COVID-19 Infant General Chemistry biology.organism_classification Virology United States 030104 developmental biology Evolutionary biology lcsh:Q Basic reproduction number 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-19248-0 |
| Popis: | Full genome sequences are increasingly used to track the geographic spread and transmission dynamics of viral pathogens. Here, with a focus on Israel, we sequence 212 SARS-CoV-2 sequences and use them to perform a comprehensive analysis to trace the origins and spread of the virus. We find that travelers returning from the United States of America significantly contributed to viral spread in Israel, more than their proportion in incoming infected travelers. Using phylodynamic analysis, we estimate that the basic reproduction number of the virus was initially around 2.5, dropping by more than two-thirds following the implementation of social distancing measures. We further report high levels of transmission heterogeneity in SARS-CoV-2 spread, with between 2-10% of infected individuals resulting in 80% of secondary infections. Overall, our findings demonstrate the effectiveness of social distancing measures for reducing viral spread. In this study, Adi Stern and colleagues use full genome sequences of SARS-CoV-2 to look at the rate of infections in Israel. They report that social distancing had a significant effect on minimising the rate of transmission, and find evidence for transmission heterogeneity (superspreading events). |
| Databáze: | OpenAIRE |
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