Organocatalytic Highly Enantioselective Synthesis of β-Formyl-α-hydroxyphosphonates

Autor:	Cong Gui Zhao, Laxmidhar Rout, Qunsheng Guo, Long Wang, Bin Zhang, Sandun Perera, Vijaya Kumar Naganaboina
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Ketone Enantioselective synthesis Acetaldehyde General Chemistry Aldehyde Chemical synthesis Article Catalysis chemistry.chemical_compound chemistry Organocatalysis Organic chemistry Aldol condensation
Zdroj:	Advanced Synthesis & Catalysis. 353:1729-1734
ISSN:	1615-4150
DOI:	10.1002/adsc.201000835
Popis:	The cross aldol reaction between enolizable aldehydes and α-ketophosphonates was achieved for the first time by using 9-amino-9-deoxy-epi-quinine as the catalyst. β-Formyl-α-hydroxyphosphonates were obtained in high to excellent enantioselectivities. The reaction works especially well with acetaldehyde, which is a tough substrate for organocatalyzed cross aldol reactions. The products were demonstrated to have anticancer activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f816e17811fdfc8c3fca8c72004484 https://doi.org/10.1002/adsc.201000835 Zobrazit plný text záznamu Plný text