Bayesian Nonparametric ROC Regression Modeling

Autor: Timothy Hanson, Miguel de Carvalho, Vanda Inacio de Carvalho, Alejandro Jara
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Bayesian Anal. 8, no. 3 (2013), 623-646
BAYESIAN ANALYSIS
Artículos CONICYT
CONICYT Chile
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Calhau Fernandes Inacio De Carvalho, V, Jara, A, Hanson, T E & de Carvalho, M 2013, ' Bayesian Nonparametric ROC Regression Modeling ', Bayesian analysis, vol. 8, no. 3, pp. 623-646 . https://doi.org/10.1214/13-BA825
Popis: The receiver operating characteristic (ROC) curve is the most widely used measure for evaluating the discriminatory performance of a continuous biomarker. Incorporating covariates in the analysis can potentially enhance information gath- ered from the biomarker, as its discriminatory ability may depend on these. In this paper we propose a dependent Bayesian nonparametric model for conditional ROC estimation. Our model is based on dependent Dirichlet processes, where the covariate-dependent ROC curves are indirectly modeled using probability models for related probability distributions in the diseased and healthy groups. Our ap- proach allows for the entire distribution in each group to change as a function of the covariates, provides exact posterior inference up to a Monte Carlo error, and can easily accommodate multiple continuous and categorical predictors. Simula- tion results suggest that, regarding the mean squared error, our approach performs better than its competitors for small sample sizes and nonlinear scenarios. The proposed model is applied to data concerning diagnosis of diabetes.
Databáze: OpenAIRE