Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals
| Autor: | Trent Nicol, Abigail M. Fellows, Brandon Vilarello, Albert Magohe, Enica Richard Massawe, Jay C. Buckey, Ndeserua Moshi, Catherine C. Rieke, Travis White-Schwoch, Nina Kraus |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Central nervous system Human immunodeficiency virus (HIV) HIV Infections Audiology medicine.disease_cause Tanzania Article 050105 experimental psychology Young Adult 03 medical and health sciences 0302 clinical medicine Hearing Physiology (medical) Hiv infected medicine Humans Speech 0501 psychology and cognitive sciences Set (psychology) business.industry 05 social sciences Outcome measures virus diseases Electroencephalography Middle Aged Neurophysiology Frequency following response Sensory Systems Formant medicine.anatomical_structure Neurology Auditory Perception Evoked Potentials Auditory Speech Perception Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Clin Neurophysiol |
| ISSN: | 1388-2457 |
| Popis: | Objective To test the hypothesis that human immunodeficiency virus (HIV) affects auditory-neurophysiological functions. Methods A convenience sample of 68 HIV+ and 59 HIV- normal-hearing adults was selected from a study set in Dar es Salaam, Tanzania. The speech-evoked frequency-following response (FFR), an objective measure of auditory function, was collected. Outcome measures were FFRs to the fundamental frequency (F0) and to harmonics corresponding to the first formant (F1), two behaviorally relevant cues for understanding speech. Results The HIV+ group had weaker responses to the F1 than the HIV- group; this effect generalized across multiple stimuli (d = 0.59). Responses to the F0 were similar between groups. Conclusions Auditory-neurophysiological responses differ between HIV+ and HIV- adults despite normal hearing thresholds. Significance The FFR may reflect HIV-associated central nervous system dysfunction that manifests as disrupted auditory processing of speech harmonics corresponding to the first formant. |
| Databáze: | OpenAIRE |
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