Bioactive constituents from Iryanthera megistophylla
| Autor: | C. J. French, Jim B. Hudson, Andrés Lopez, Brian J. Hillhouse, Dong Sheng Ming, G. H. N. Towers |
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| Rok vydání: | 2002 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Pharmacognosy Analytical Chemistry Myristicaceae chemistry.chemical_compound Biological Factors Drug Discovery Phenols Antibacterial agent Pharmacology chemistry.chemical_classification biology Spectrum Analysis Organic Chemistry biology.organism_classification Complementary and alternative medicine Proanthocyanidin chemistry visual_art visual_art.visual_art_medium Molecular Medicine Iryanthera Bark Lactone |
| Zdroj: | Journal of natural products. 65(10) |
| ISSN: | 0163-3864 |
| Popis: | Activity-guided fractionation of the 95% ethanol extract from the stem bark of Iryanthera megistophylla led to the isolation of two new compounds, named megislignan [2,3-dimethyl-4-(4-methoxyphenyl)-6-hydroxynaphthalene] (1) and megislactone [(2R,3R,4R)-3-hydroxy-4-methyl-2-(hexacos-17-enyl)butanolide] (2), along with seven known compounds, grandinolide (3), iryantherin K (4), iryantherin L (5), cinchonain I b (6), cinchonain I a (7), procyanidin B-2 (8), and cinchonain IIa (9). The structures of the new compounds were elucidated by spectral data interpretation. Isolates were evaluated for their antibacterial, antifungal, antiviral, and antiacetylcholinesterase activities. |
| Databáze: | OpenAIRE |
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