Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial

Autor: Colin A. Graham, William W.K. Woo, Yuk Ki Leung, Ling Yan Leung, Giles N. Cattermole, S. Y. Man, Ronson S.L. Lo, Kevin K C Hung, Timothy H. Rainer
Rok vydání: 2017
Předmět:
Male
Critical Care and Emergency Medicine
NSAIDs
lcsh:Medicine
Administration
Oral
Ibuprofen
Pathology and Laboratory Medicine
law.invention
0302 clinical medicine
Randomized controlled trial
law
Medicine and Health Sciences
Medicine
030212 general & internal medicine
lcsh:Science
Analgesics
Multidisciplinary
Pharmaceutics
Drugs
Middle Aged
Research Design
Anesthesia
Female
Anatomy
medicine.drug
Research Article
Soft Tissue Injuries
Side effect
Soft Tissues
Clinical Research Design
Analgesic
Lower Back Pain
Pain
Research and Analysis Methods
03 medical and health sciences
Signs and Symptoms
Double-Blind Method
Adverse Reactions
Drug Therapy
Diagnostic Medicine
Humans
Pain Management
Acetaminophen
Pharmacology
Intention-to-treat analysis
business.industry
organic chemicals
lcsh:R
Infant
Newborn
Biology and Life Sciences
030208 emergency & critical care medicine
Emergency department
medicine.disease
Biological Tissue
Soft tissue injury
lcsh:Q
Adverse Events
Analgesia
business
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192043 (2018)
ISSN: 1932-6203
Popis: Background Soft tissue injuries commonly present to the emergency department (ED), often with acute pain. They cause significant suffering and morbidity if not adequately treated. Paracetamol and ibuprofen are commonly used analgesics, but it remains unknown if either one or the combination of both is superior for pain control. Objectives To investigate the analgesic effect of paracetamol, ibuprofen and the combination of both in the treatment of soft tissue injury in an ED, and the side effect profile of these drugs. Methods Double-blind, double dummy, placebo-controlled randomised controlled trial. 782 adult patients presenting with soft tissue injury without obvious fractures attending the ED of a university hospital in the New Territories of Hong Kong were recruited. Patients were randomised using a random number table into three parallel arms of paracetamol only, ibuprofen only and a combination of paracetamol and ibuprofen in a 1:1:1 ratio. The primary outcome measure was pain score at rest and on activity in the first 2 hours and first 3 days. Data was analysed on an intention to treat basis. Results There was no statistically significant difference in pain score in the initial two hours between the three groups, and no clinically significant difference in pain score in the first three days. Conclusion There was no difference in analgesic effects or side effects observed using oral paracetamol, ibuprofen or a combination of both in patients with mild to moderate pain after soft tissue injuries attending the ED. Trial registration The study is registered with ClinicalTrials.gov (no. NCT00528658).
Databáze: OpenAIRE
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