Effects of clomipramine on plasma amino acids and serotonergic parameters in panic disorder and depression
| Autor: | Leo Timmerman, Lolke Pepplinkhuizen, Durk Fekkes |
|---|---|
| Přispěvatelé: | Psychiatry |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Blood Platelets Male Serotonin medicine.medical_specialty Clomipramine medicine.drug_class Tricyclic antidepressant Antidepressive Agents Tricyclic Serotonergic Internal medicine medicine Humans Pharmacology (medical) Platelet Amino Acids Biological Psychiatry Psychiatric Status Rating Scales Pharmacology Depressive Disorder business.industry Panic disorder Tryptophan medicine.disease Discontinuation Psychiatry and Mental health Endocrinology Neurology Panic Disorder Tyrosine Female Neurology (clinical) business Follow-Up Studies medicine.drug |
| Zdroj: | European Neuropsychopharmacology, 235-239. Elsevier ISSUE=7;STARTPAGE=235;ENDPAGE=239;ISSN=0924-977X;TITLE=European Neuropsychopharmacology |
| ISSN: | 0924-977X |
| DOI: | 10.1016/s0924-977x(97)00412-4 |
| Popis: | We examined the effects of long-term (six months) treatment with the serotonin potentiating tricyclic antidepressant clomipramine on several serotonergic parameters in panic disorder and depressive patients. Serotonin (5-HT) levels in blood, platelets and plasma were significantly reduced to 4%, 3% and 28% of their respective baseline values. In addition, the plasma level of tryptophan was also significantly reduced, although the decrease was only 16%. Three months after discontinuation of clomipramine treatment, 5-HT in blood and platelets reached baseline values again, while the plasma 5-HT level was still reduced to 68% of pretreatment values. Unexpectedly, the plasma tryptophan concentration was even lower at this time-point than after six months of treatment. These results show that clomipramine not only has an effect on 5-HT levels in blood, platelets and plasma, but also on plasma tryptophan concentration. We speculate that low plasma tryptophan after treatment may constitute a risk for the recurrence of psychopathology. |
| Databáze: | OpenAIRE |
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