Trypanosoma brucei colonises the tsetse gut via an immature peritrophic matrix in the proventriculus
| Autor: | Ben Middlehurst, Alvaro Acosta-Serrano, Ian A. Prior, Aitor Casas-Sanchez, Naomi A. Dyer, Marco Marcello, Alison J. Beckett, Clair Rose, Michael J. Lehane, Carla Solórzano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
biology Salivary gland 030231 tropical medicine Proventriculus Midgut Trypanosoma brucei biology.organism_classification Microbiology Gut Epithelium Colonisation 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure parasitic diseases medicine Parasite transmission Peritrophic matrix 030304 developmental biology |
| Popis: | The peritrophic matrix (PM) of haematophagus insects is a chitinous structure that surrounds the bloodmeal, forming a protective barrier against oral pathogens and abrasive particles. To establish an infection in the tsetse midgut,Trypanosoma bruceimust colonise the ectoperitrophic space (ES), located between the PM and gut epithelium. Although unproven, it is generally accepted that trypanosomes reach the ES by directly penetrating the PM in the anterior midgut. Here we revisited this event by employing novel fluorescence and electron microscopy methodologies and found that instead, trypanosomes reach the ES via the newly secreted PM in the tsetse proventriculus. Within this model, parasites colonising the proventriculus can either migrate to the ES or become trapped within PM layers forming cysts that move along the entire gut as the PM gets remodelled. Early proventricular colonisation appears to be promoted by unidentified factors in trypanosome-infected blood, resulting in higher salivary gland infections and potentially increasing parasite transmission. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|