Hypopharyngeal squamous cell carcinoma bordering ectopic gastric mucosa 'inlet patch' of the cervical esophagus
| Autor: | Shuji Toda, Akira Inokuchi, Shintaro Satoh, Yuichiro Kuratomi, Keiko Watanabe, Hajime Sugihara, Toshiyuki Nakashima |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Choristoma Esophageal Diseases Gastroenterology Lesion Hypopharyngeal Carcinoma Internal medicine medicine Humans Esophagus Gastrin Hypopharyngeal Neoplasms business.industry Neck dissection General Medicine digestive system diseases Laryngectomy medicine.anatomical_structure Otorhinolaryngology Gastric Mucosa Esophagectomy Carcinoma Squamous Cell Gastric acid Female Surgery medicine.symptom business |
| Zdroj: | Auris Nasus Larynx. 34:135-139 |
| ISSN: | 0385-8146 |
| DOI: | 10.1016/j.anl.2006.05.014 |
| Popis: | Objective Ectopic gastric mucosa of the cervical esophagus, referred to as inlet patch (IP), is considered to be a common development abnormality of the esophagus. We report here a case of hypopharyngeal squamous cell carcinoma bordering on IP of the cervical esophagus. Methods A 44-year-old female underwent partial pharyngectomy, total laryngectomy, cervical esophagectomy, and bilateral neck dissection under the diagnosis of hypopharyngeal carcinoma. Results Resected specimens of the hypopharynx revealed a well-differentiated squamous cell carcinoma in the ulcerative tumorous lesion (3.5 cm × 0.5 cm). A brown patch (2 cm × 1.5 cm) bordering the anal aspect of the tumor comprised ectopic gastric mucosa of fundic type epithelium. Immunohistochemistry revealed the surface mucosal cells of this lesion were strongly positive for human gastric mucin (HGM) and the fundic cells were positive for gastrin. Conclusion The hypopharyngeal squamous cell carcinoma likely developed in association with chronic irritation due to gastric acid from the IP. To our knowledge, this is the first reported case of squamous cell carcinoma related to IP. |
| Databáze: | OpenAIRE |
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