Leptin stimulates the release of pro-inflammatory cytokines in hypothalamic astrocyte cultures from adult and aged rats
Autor: | Diogo O. Souza, Larissa Daniele Bobermin, André Quincozes-Santos, Camila Leite Santos |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Leptin Male medicine.medical_specialty Aging medicine.medical_treatment Hypothalamus Adipose tissue Biochemistry Energy homeostasis Proinflammatory cytokine 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine medicine Animals Rats Wistar Neuroinflammation Cells Cultured business.industry digestive oral and skin physiology Rats Interleukin 10 030104 developmental biology Cytokine Endocrinology Animals Newborn Astrocytes Cytokines Neurology (clinical) Inflammation Mediators business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
Zdroj: | Metabolic brain disease. 33(6) |
ISSN: | 1573-7365 |
Popis: | Leptin is an adipose tissue-derived hormone that acts on the hypothalamus in order to maintain energy homeostasis. However, leptin can also induce an inflammatory response. Increasing evidence has highlighted a critical role of astrocytes in the effects of leptin on the hypothalamus. In addition, astrocytes participate in neuroinflammation by producing and releasing a wide range of inflammatory mediators. In this study, we aimed to investigate the age-dependent effect of leptin on pro- and anti-inflammatory cytokines released by the hypothalamic astrocyte cultures obtained from newborn, adult, and aged Wistar rats. In hypothalamic astrocytes from newborn rats, leptin did not change the release of pro-inflammatory cytokines, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β). On the other contrary, leptin increased the release of both TNF-α and IL-1β in astrocyte cultures from adult and aged animals. Regarding the anti-inflammatory cytokine interleukin 10 (IL-10), we did not observe any change in response to leptin. In conclusion, our data suggests a pro-inflammatory action of leptin on the hypothalamus during aging. This in turn may be related to the triggering of metabolic disorders, as both of these conditions are associated with neuroinflammation. |
Databáze: | OpenAIRE |
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