Identification of Bithionol, Dichlorophen, and Miconazole as Antibacterial Agents against Acinetobacter calcoaceticus
| Autor: | Jean Patrick Gonzalez Dahua, Mikhail Martchenko Shilman, Tiffany H Khaw, Genevieve Herle, Adhitya Logan, S N Michael Wong, Anastasia Levitin, Saleem Alameh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
biology
General Chemical Engineering Pathogenic bacteria General Chemistry Acinetobacter medicine.disease_cause biology.organism_classification Article Microbiology chemistry.chemical_compound Chemistry Animal model Bithionol chemistry medicine bacteria Acinetobacter calcoaceticus Miconazole Dichlorophen QD1-999 Bacteria medicine.drug |
| Zdroj: | ACS Omega ACS Omega, Vol 5, Iss 37, Pp 23951-23959 (2020) |
| ISSN: | 2470-1343 |
| Popis: | The rising prevalence of multidrug-resistant hospital-acquired infections has increased the need for new antibacterial agents. In this study, a library of 1586 FDA-approved drugs was screened against A. calcoaceticus, a representative of the Acinetobacter calcoaceticus-baumannii complex. Three compounds were found to have previously undiscovered antibacterial properties against A. calcoaceticus: antifungal Miconazole, anthelminthic Dichlorophen, and Bithionol. These three drugs were tested against a wide range of Gram-positive and Gram-negative bacteria and confirmed to have broad-spectrum antibacterial properties. Combinations of these three drugs were also tested against the same bacteria, and two novel combination therapies with synergistic effects were discovered. In the future, antibacterial properties of these three drugs and two combination therapies will be evaluated against pathogenic bacteria using an animal model. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|