Synthesis and Characterisation of First Generation Luminescent Lanthanide Complexes Suitable for Being Adapted for Uptake via the Mannose Receptor

Autor:	Sally E. Plush, Zhangli Du, Glenn N. Borlace, Douglas A. Brooks, Robert Darren Brooks
Přispěvatelé:	Brooks, Robert, Du, Zhangli, Borlace, Glenn, Brooks, Douglas, Plush, Sally
Rok vydání:	2013
Předmět:	Lanthanide body composition child obesity muscle Chemistry Inorganic chemistry Mannose Photochemistry Fluorescence First generation chemistry.chemical_compound Residue (chemistry) adolescent muscle strength overweight resistance training Luminescence Phosphorescence Mannose receptor
Zdroj:	Journal of Inorganic Chemistry. 2013:1-8
ISSN:	2314-713X
Popis:	With the aim of directing lanthanide complex uptake via the mannose receptor, a first generation of luminescent lanthanide complexes has been developed with an α-D-mannose targeting motif. Four complexes were produced to investigate photophysical properties and determine the effect of the coordinated mannose residue on emission intensity. The free hydroxyls of the α-D-mannose residue quenched lanthanide phosphorescence due to their close proximity, though they did not bind the lanthanide centre as observed by q-values ≈1.0 for all complexes between pH 3 and 10. Fluorescent emission was found to vary significantly with pH, though phosphorescent emission was relatively insensitive to pH. This lack of pH sensitivity has the potential to provide stable emission for the visualisation of the endosome-lysosome system where acidic pH is often encountered.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e87ea537041d9c2995cefa3da1868d https://doi.org/10.1155/2013/498598 Zobrazit plný text záznamu Plný text