The Skin Prick Test is Not Useful in the Diagnosis of the Immediate Type Food Allergy Tolerance Acquisition
| Autor: | Takatsugu Komata, Takanori Imai, Motohiro Ebisawa, Mika Ogata, Noriyuki Yanagida, Morimitsu Tomikawa |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Male food hypersensitivity Allergy medicine.medical_specialty Eggs Wheat Hypersensitivity Immunoglobulin E medicine.disease_cause Immune tolerance tolerance acquisition Allergen Antibody Specificity oral food challenge Food allergy Immune Tolerance medicine Animals Humans Immunology and Allergy Child Retrospective Studies Skin Tests food allergy biology business.industry Oral food challenge Infant Wheal Size General Medicine Allergens medicine.disease Dermatology skin prick test Milk ROC Curve Child Preschool Immunology biology.protein Cattle Female lcsh:RC581-607 business Egg white |
| Zdroj: | Allergology International, Vol 63, Iss 2, Pp 205-210 (2014) |
| ISSN: | 1323-8930 |
| DOI: | 10.2332/allergolint.12-oa-0513 |
| Popis: | Background : Some studies have been reported about positioning of SPT in the diagnosis of food allergy. On the other hand, it is not yet clear about the positioning of SPT in the diagnosis of tolerance acquisition of the immediate type food allergy. Methods The retrospective study had been conducted for 236 egg allergic children (51.3 months in mean), 127 milk allergic children (53.4 months), and 96 wheat allergic children (42.6 months). The retrospective analysis of serum nonspecific and antigen-specific IgE levels, SPT, and OFC had been conducted for each allergic patient. All OFC had been conducted to verify the acquisition of tolerance against eliminated food. Results: The OFC was positive in 61 (25.8%) hen's egg allergies, 34 (26.8%) milk allergies and 33 (34.4%) wheat allergies. The greatest AUC for each allergen is as following; hen's egg for egg white specific IgE at 0.745, milk/histamine (wheal) index at 0.718, and wheat for wheal size at 0.597. For the predictive decision points, the highest accuracy rate was at 25.8% for an egg white wheal of 9.5 mm, at 26.8% for a milk wheal of 9.5 mm, and at 34.4% for a wheal of 6.5 mm. Conclusions As a result of this analysis, the diagnostic accuracy of SPT had not been satisfactory to judge the acquisition of tolerance in allergic children for eggs, milk and wheat. Therefore, this is not a strong evidence to testify the tolerance of the immediate type food allergy. |
| Databáze: | OpenAIRE |
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