Nocturnal Oxygen Desaturation and Disordered Sleep as a Potential Factor in Executive Dysfunction in Sickle Cell Anemia
| Autor: | Baba Inusa, Michael R. DeBaun, Tessa B. Kok, Matthew J. Hollocks, Johanna Gavlak, Fenella J. Kirkham, Michelle de Haan |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Sleep Wake Disorders medicine.medical_specialty Adolescent Anemia Polysomnography Intelligence Statistics as Topic Anemia Sickle Cell Neuropsychological Tests Article Executive Function Hemoglobins Internal medicine medicine Humans Oximetry Child Psychiatry Stroke Retrospective Studies Intelligence Tests medicine.diagnostic_test General Neuroscience Neuropsychology medicine.disease Magnetic Resonance Imaging Sickle cell anemia Oxygen Psychiatry and Mental health Clinical Psychology Sleep Arousal Disorders Cardiology Female Neurology (clinical) Cognition Disorders Psychology Executive dysfunction |
| Zdroj: | Journal of the International Neuropsychological Society. 18:168-173 |
| ISSN: | 1469-7661 1355-6177 |
| DOI: | 10.1017/s1355617711001469 |
| Popis: | Previous research has identified cognitive impairment in children with sickle cell anemia (SCA, Hemoglobin SS) compared with controls, partly accounted for by overt neuropathology after clinical stroke, “covert” (“silent”) infarction, and severity of anemia. However, cognitive deficits have also been identified in children with SCA with no history of stroke and a normal T2-weighted magnetic resonance imaging (MRI) scan. Our aim was to investigate whether nocturnal hemoglobin oxygen desaturation and sleep fragmentation could be associated with cognitive impairment in children with SCA. We assessed 10 children with SCA (9 with normal MRI) using neuropsychological measures of executive function. Cognitive assessment was immediately followed by overnight polysomnography to record nocturnal hemoglobin oxygen saturation and sleep arousals. Decreases in hemoglobin oxygen saturation and/or increased sleep arousals were associated with reduced performance on cognitive assessment. Nocturnal hemoglobin oxygen desaturation and sleep fragmentation may be a contributing factor to executive dysfunction in SCA. (JINS, 2012, 18, 168–173) |
| Databáze: | OpenAIRE |
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