Biodegradable electrospun PLLA fibers containing the mosquito-repellent DEET
| Autor: | Michael Göbel, René Androsch, Irene Bonadies, Alessandra Longo, Dieter Jehnichen, Maria Laura Di Lorenzo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Electrospinning Polymers and Plastics fungi Organic Chemistry General Physics and Astronomy 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Controlled release N-diethyl-3-methylbenzamide (DEET) 0104 chemical sciences Thermogravimetry DEET chemistry.chemical_compound Crystallinity chemistry Chemical engineering Drug delivery Materials Chemistry 0210 nano-technology Poly(l-lactic acid) (PLLA) |
| Zdroj: | European Polymer Journal 113 (2019). doi:10.1016/j.eurpolymj.2019.02.001 info:cnr-pdr/source/autori:Irene Bonadies, Alessandra Longo, René Androsch, Dieter Jehnichen, Michael Göbel, Maria Laura Di Lorenzo/titolo:Biodegradable Electrospun PLLA Fibers Containing the Mosquito-Repellent DEET/doi:10.1016%2Fj.eurpolymj.2019.02.001/rivista:European Polymer Journal/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:113 |
| ISSN: | 0014-3057 |
| DOI: | 10.1016/j.eurpolymj.2019.02.001 |
| Popis: | The manuscript details the first literature example of fibers of poly( l -lactic acid) (PLLA) containing a mosquito repellent agent, N,N-diethyl-3-methylbenzamide (DEET). The fibers were prepared by electrospinning, are defect-free and have uniform diameter of the order of magnitude of 1 µm. Thermogravimetry and infrared spectroscopy showed that it is possible to incorporate more than 50 wt% of DEET, which is then slowly released to the environment. As such, the fibers can function as a drug delivery device. Further structural analyses disclosed that PLLA in DEET-containing fibers is semicrystalline, and contains α-crystals formed during electrospinning. Thermal, morphological and structural characterization revealed that the PLLA/DEET electrospun fibers have potential as novel material for controlled release of DEET, which, coupled with the ease of fabrication, detailed here, can provide innovative tools for fighting mosquito-caused diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect