Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma
| Autor: | Sedivý J, Bohdanecká M, Chadimová M, K. Matoušovic, Schück O, M. Krajíčková |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Clinical chemistry Kinetics Kidney urologic and male genital diseases Nephrectomy Pharmacokinetics Oral administration Internal medicine Parenchyma medicine Animals Pharmacology (medical) Renal Insufficiency Pharmacology business.industry Ciclosporin medicine.disease Rats Endocrinology Cyclosporine Complication business Immunosuppressive Agents medicine.drug Kidney disease |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 22:207-209 |
| ISSN: | 2107-0180 0378-7966 |
| Popis: | Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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