Intraoperative Localization of Tantalum Markers for Proton Beam Radiation of Choroidal Melanoma by an Opto-Electronic Navigation System: A Novel Technique
| Autor: | Michael H. Foerster, Jens Kowal, Jens Heufelder, Nikolaos E. Bechrakis, Christoph Amstutz |
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| Rok vydání: | 2012 |
| Předmět: |
Uveal Neoplasms
Choroidal melanoma Cancer Research medicine.medical_specialty Accuracy and precision Swine medicine.medical_treatment Tantalum chemistry.chemical_element Pilot Projects Software Fiducial Markers Proton Therapy Animals Humans Medicine Radiology Nuclear Medicine and imaging Medical physics Melanoma Proton therapy Radiation business.industry Choroid Neoplasms Radiotherapy Planning Computer-Assisted Navigation system Radiation therapy Oncology chemistry Remote Sensing Technology business Fiducial marker Organ Sparing Treatments Sclera Biomedical engineering |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 82:1361-1366 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2011.04.049 |
| Popis: | Purpose External beam proton radiation therapy has been used since 1975 to treat choroidal melanoma. For tumor location determination during proton radiation treatment, surgical tantalum clips are registered with image data. This report introduces the intraoperative application of an opto-electronic navigation system to determine with high precision the position of the tantalum markers and their spatial relationship to the tumor and anatomical landmarks. The application of the technique in the first 4 patients is described. Methods and Materials A navigated reference base was attached noninvasively to the eye, and a navigated pointer device was used to record the spatial position of the tantalum markers, the tumor, and anatomical landmarks. Measurement accuracy was assessed on ex vivo porcine eye specimen by repetitive recording of the tantalum marker positions. The method was applied intraoperatively on 4 patients undergoing routine tantalum clip surgery. The spatial position information delivered by the navigation system was compared to the geometric data generated by the EYEPLAN software. Results In the ex vivo experiments, the maximum repetition error was 0.34 mm. For the intraoperative application, the root mean square error of paired-points matching of the marker positions from the navigation system and from the EYEPLAN software was 0.701–1.25 mm. Conclusions Navigation systems are a feasible tool for accurate localization of tantalum markers and anatomic landmarks. They can provide additional geometric information, and therefore have the potential to increase the reliability and accuracy of external beam proton radiation therapy for choroidal melanoma. |
| Databáze: | OpenAIRE |
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