Bariatric Surgery Affects Plasma Levels of Alanine Aminotransferase Independent of Weight Loss: A Registry-Based Study
| Autor: | Shira Azulai, Ronit Grinbaum, Rachel Ben-Haroush Schyr, Shai Carmi, Shai Meron Eldar, Orly Romano-Zelekha, Danny Ben-Zvi, Moshe Rubin, Nahum Beglaibter |
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| Rok vydání: | 2021 |
| Předmět: |
OAGB
obesity Sleeve gastrectomy medicine.medical_specialty ALT bariatric surgery medicine.medical_treatment 030209 endocrinology & metabolism registry digestive system Article 03 medical and health sciences 0302 clinical medicine RYGB Weight loss Medicine Clinical significance Alanine aminotransferase AST business.industry General Medicine Plasma levels medicine.disease Obesity A1C digestive system diseases 3. Good health Surgery Cohort 030211 gastroenterology & hepatology Liver function medicine.symptom business sleeve gastrectomy |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 12 Journal of Clinical Medicine, Vol 10, Iss 2724, p 2724 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10122724 |
| Popis: | Patients that undergo bariatric surgery experience weight loss and a reduction in the plasma levels of the hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST). We used the Israeli national bariatric registry, which includes demographic, clinical, and biochemical data on 19,403 patients, of which 1335 patients had two-year follow-up data on ALT, AST, A1C, and BMI, to test the dependence of the reduction in the levels of ALT and AST on weight loss. The data were analyzed using regression models, retrospective matching, and time course analyses. Changes in liver enzymes did not correlate with change in BMI, and linear regression models did not demonstrate that the change in ALT and AST values were dependent on pre-operative levels of BMI or the extent of weight loss. ALT and AST levels were reduced two years after surgery compared with a cohort of retrospectively matched patients for ethnicity, sex, age, BMI, and A1C. Finally, patients who regained weight displayed a reduction in levels of liver enzymes. Our results suggest that bariatric surgery affects AST and ALT levels via weight loss dependent and independent mechanisms. Mechanistic studies that will identify the nature of this effect and the clinical relevance of ALT and AST levels to the post-bariatric liver function are warranted. |
| Databáze: | OpenAIRE |
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