Evaluation of Sustained-Release Steroid Hydrogels in a Guinea Pig Model for Noise-Induced Hearing Loss
| Autor: | Franz Gabor, Julia Clara Gausterer, Clemens Honeder, Michael Nieratschker, Nodir Saidov, Navid Ahmadi, Hanna Schöpper, Christoph Arnoldner, Chengjing Zhu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Triamcinolone acetonide Physiology Hearing loss Guinea Pigs Triamcinolone Acetonide Dexamethasone 03 medical and health sciences Speech and Hearing 0302 clinical medicine Hearing Internal medicine otorhinolaryngologic diseases medicine Animals 030223 otorhinolaryngology Glucocorticoids Cochlea Spiral ganglion Absolute threshold of hearing business.industry Auditory Threshold Hydrogels medicine.disease Sensory Systems Disease Models Animal medicine.anatomical_structure Endocrinology Hearing Loss Noise-Induced Otorhinolaryngology Delayed-Action Preparations Female Hair cell medicine.symptom business 030217 neurology & neurosurgery Noise-induced hearing loss medicine.drug |
| Zdroj: | Audiology and Neurotology. 23:73-81 |
| ISSN: | 1421-9700 1420-3030 |
| Popis: | The otoprotective effects of thermoreversible poloxamer 407 hydrogels containing dexamethasone or triamcinolone acetonide were evaluated in an animal model of noise-induced hearing loss. Seven days after noise exposure, hearing threshold shifts at 16 kHz were significantly reduced in the 6% dexamethasone group (p < 0.05). Even though no significant differences in hair cell counts were found, histological analysis revealed a significantly higher spiral ganglion cell density in the first turn of the cochlea in this group (p < 0.05). No otoprotective effects were observed after the application of the triamcinolone acetonide hydrogels. As the findings of this study indicate potential otoprotective effects of sustained topical dexamethasone delivery in the setting of noise-induced hearing loss, this strategy merits further evaluation. |
| Databáze: | OpenAIRE |
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