Crosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation
| Autor: | Sharad Kumar, Donna Denton, Shannon Nicolson, Tianqi Xu, Sonia Dayan |
|---|---|
| Přispěvatelé: | Denton, Donna, Xu, Tianqi, Dayan, Sonia, Nicolson, Shannon, Kumar, Sharad |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
Programmed cell death animal structures Immunology Article 03 medical and health sciences Cellular and Molecular Neuroscience Lysosome medicine Autophagy Animals Drosophila Proteins lcsh:QH573-671 030304 developmental biology 0303 health sciences Decapentaplegic delivery to the lysosome Chemistry lcsh:Cytology TOR Serine-Threonine Kinases 030302 biochemistry & molecular biology fungi Midgut Cell Biology TOR signaling Cell biology programmed cell death (PCD) medicine.anatomical_structure regulation of cell growth Gene Knockdown Techniques Larva Drosophila Signal transduction Digestive System Signal Transduction |
| Zdroj: | Cell Death & Disease Cell Death and Disease, Vol 10, Iss 2, Pp 1-8 (2019) |
| Popis: | The majority of developmentally programmed cell death (PCD) is mediated by caspase-dependent apoptosis; however, additional modalities, including autophagy-dependent cell death, have important spatiotemporally restricted functions. Autophagy involves the engulfment of cytoplasmic components in a double membrane vesicle for delivery to the lysosome. An established model for autophagy-dependent PCD is Drosophila larval midgut removal during metamorphosis. Our previous work demonstrated that growth arrest is required to initiate autophagy-dependent midgut degradation and Target of rapamycin (Tor) limits autophagy induction. In further studies, we uncovered a role for Decapentaplegic (Dpp) in coordinating midgut degradation. Here, we provide new data to show that Dpp interacts with Tor during midgut degradation. Inhibiting Tor rescued the block in midgut degradation due to Dpp signaling. We propose that Dpp is upstream of Tor and down-regulation promotes growth arrest and autophagy-dependent midgut degradation. These findings underscore a relationship between Dpp and Tor signaling in the regulation of cell growth and tissue removal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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