Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus
| Autor: | Subrata K. Biswas, Sheikh M.K. Alam, Mohammed K. Ali, Shahana Jasmin, M I Arslan, Sonam C. R, Sonchita R. Mudi, Mohammad Fariduddin, Mokerroma Ferdous |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Inflammation Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus Leukocytes Internal Medicine medicine Humans Peroxidase biology business.industry Insulin Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Cross-Sectional Studies 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Case-Control Studies Myeloperoxidase Neutrophil elastase biology.protein Female medicine.symptom Leukocyte Elastase business |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 14:83-85 |
| ISSN: | 1871-4021 |
| Popis: | Background and aims Neutrophil elastase and myeloperoxidase enzymes protect us from infection by killing pathogens. However, exaggerated activities of these enzymes can induce tissue damage, inflammation and oxidative stress. The present study was aimed to explore the expressions of neutrophil elastase and myeloperoxidase mRNA in the peripheral blood leukocytes (PBL) in patients with newly diagnosed type 2 diabetes mellitus. Methods In this cross-sectional study, 104 participants including 65 normoglycemic control subjects and 39 newly diagnosed type 2 diabetes patients were recruited. Glycemic and metabolic markers were evaluated from fasting blood samples. The mRNA levels of neutrophil elastase and myeloperoxidase genes in the PBL were quantified by real-time quantitative PCR. Results Compared to control subjects, diabetes patients showed a significant down regulation of both neutrophil elastase (p = 0.039) and myeloperoxidase (p = 0.023) mRNA expressions in the PBL. The neutrophil elastase and myeloperoxidase mRNA levels showed a negative trend with fasting glucose levels but did not show any significant correlations with HbA1c, insulin level, insulin resistance or sensitivity status. Conclusions It was concluded that type 2 diabetes mellitus is associated with a decrease in neutrophil elastase and myeloperoxidase gene expression in the PBL. |
| Databáze: | OpenAIRE |
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