Kinetic models for insulin disappearance from plasma in type I diabetic patients
| Autor: | Karsten Ellemann, Steen Fugleberg, Bo Feldt-Rasmussen, C. Binder, B. Thorsteinsson, Ole Ortved Andersen |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Metabolic Clearance Rate Health Toxicology and Mutagenesis medicine.medical_treatment Kinetics Toxicology Models Biological Pharmacokinetics Internal medicine Blood plasma medicine Humans Insulin Enzyme kinetics Pharmacology biology Chemistry Plasma Middle Aged biology.organism_classification Endocrinology Diabetes Mellitus Type 1 Tasa Female Steady state (chemistry) |
| Zdroj: | Pharmacologytoxicology. 60(2) |
| ISSN: | 0901-9928 |
| Popis: | We have tested whether our previous finding in normal subjects that the disappearance of insulin from plasma obeys saturation kinetics alone also applies to type I diabetic patients. In six long-term diabetic patients steady state plasma insulin concentrations resulting from constant insulin infusion at different rates were compared with the predictions of three models for the kinetics of insulin in plasma. The models allowed the existence of non-saturable (first order equation) or saturable (Michaelis-Menten equation) mechanisms, or both. The minimal acceptable model included saturation kinetics alone in four subjects and first order kinetics alone in two subjects. The clearance of insulin in diabetic patients, calculated from the best fitting model, was 18.0 (median, range 10.0-23.7) ml X kg-1 X min.-1 versus 25.0 (18.6-47.1) ml X kg-1 X min.-1 in six normal subjects (2p = 0.008). Insulin thus disappears from plasma at a lower rate in diabetic patients than in normal subjects at physiological plasma concentrations. |
| Databáze: | OpenAIRE |
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