Erythrocyte involvement in chronic lymphocytic leukaemia
| Autor: | L. Hatskelson, N. Meyerstein, A. Dvilansky, T. Yirmiahu, U. Oppenheim |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Autoimmune disease
Hemolytic anemia Erythrocytes Lymphocytic leukaemia business.industry Chronic lymphocytic leukemia Atp content Hematology medicine.disease Leukemia Lymphoid Osmotic Fragility Red blood cell Adenosine Triphosphate medicine.anatomical_structure immune system diseases hemic and lymphatic diseases Immunology medicine Humans Lymphoproliferative disease business neoplasms Whole blood |
| Zdroj: | Scandinavian Journal of Haematology. 36:138-141 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1986.tb00817.x |
| Popis: | Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disorder which sometimes also affects the erythrocytes. In this study we investigated erythrocyte involvement in 23 CLL patients. We found increased erythrocyte osmotic fragility in 15 CLL patients, but this finding was not accompanied by increased permeability to acidified glycerol (decreased AGLT50). Only those CLL patient who had positive direct antiglobulin test (DAT) had significantly decreased AGLT50. AGLT cannot serve as a predictor test for the future development of autoimmune haemolytic anaemia in CLL patients. ATP content was unaffected by the lymphoproliferative disease, but whole blood filterability was markedly decreased in CLL patients. Our study supports the hypothesis that erythrocytes are indeed affected by the lymphoproliferative disorder, even in the absence of overt autoimmune haemolytic processes. |
| Databáze: | OpenAIRE |
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