Antihyperglycaemic and hypolipidaemic effects of the methanolic extract of Caralluma tuberculata in streptozotocin-induced diabetic rats
| Autor: | Essam Abdel-Sattar, Salah A. Gabr, Fathalla M. Harraz, Salah A. Ghareib, Mansour I. Suliaman, Ahmed A. Elberry |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Diabetic rat Plant Science Pharmacology Biochemistry Analytical Chemistry Diabetes Mellitus Experimental Diabetes mellitus Internal medicine Total cholesterol Medicine Animals Hypoglycemic Agents Insulin Oral glucose tolerance Triglycerides Hypolipidemic Agents Analysis of Variance business.industry Plant Extracts Methanol Organic Chemistry Glucose Tolerance Test medicine.disease Streptozotocin Rats Apocynaceae Endocrinology Cholesterol Caralluma tuberculata Plasma insulin business medicine.drug Phytotherapy |
| Zdroj: | Natural product research. 25(12) |
| ISSN: | 1478-6427 |
| Popis: | The antihyperglycaemic and hypolipidaemic effects of the methanolic extract of Caralluma tuberculata were investigated in streptozotocin (STZ)-induced diabetic rats. The antihyperglycaemic activity was assessed by the reduction in fasting blood glucose (54% at 4th week) and the peak of blood glucose at 120?min of an oral glucose tolerance test in diabetic rats. Further, the tested extract also increased plasma insulin by 206.8%. The hypolipidaemic action of the extract was evident by the significant decrease in the levels of total cholesterol, triglycerides and LDL-cholesterol by 41.5%, 36.7% and 49.1%, respectively, compared to diabetic rat values. Interestingly, the extract increased the cardio-protective lipid HDL-cholesterol by 147.97% as compared to diabetic rat value. The present data suggests that the methanolic extract of C. tuberculata has both antihyperglycaemic and hypolipidaemic effects in STZ-induced diabetic rats that may need further studies to be used in the management of diabetes and associated hyperlipedaemia. |
| Databáze: | OpenAIRE |
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