Insecticide resistance mechanisms in Anopheles gambiae complex populations from Burkina Faso, West Africa

Autor: Abdoulaye Diabaté, Mahamadi Kientega, Dieudonné Diloma Soma, Mahamoudou Balboné, Florence Fournet, Thierry Baldet, Samuel Fogné Drabo, Ahmed Y. Coulibaly, Olivier Gnankiné, Moussa Namountougou, Didier Alexandre Kaboré, Roch K. Dabiré
Přispěvatelé: Université Polytechnique Nazi Boni Bobo-Dioulasso (UNB), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut de Recherche pour le Développement (IRD), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Institut de Recherche en Sciences de la Santé (IRSS), CNRST, Université de Ouagadougou, Diversity, ecology, evolution & Adaptation of arthropod vectors (MIVEGEC-DEEVA), Evolution des Systèmes Vectoriels (ESV), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Joseph Ki-Zerbo [Ouagadougou] (UJZK), project TWAS [15-259 RG/BIO/AF/AC_G -FR3240287017]
Rok vydání: 2019
Předmět:
0301 basic medicine
Veterinary medicine
Insecticides
medicine.medical_treatment
Anopheles gambiae
H02 - Pesticides
Insecticide Resistance
chemistry.chemical_compound
0302 clinical medicine
ComputingMilieux_MISCELLANEOUS
Pyréthrine de syntèse
2. Zero hunger
Résistance aux insecticides
Organophosphate
030108 mycology & parasitology
Metabolic resistance
3. Good health
Infectious Diseases
PCR
Pyrethroids resistance
L72 - Organismes nuisibles des animaux
geographic locations
Wet season
Carbamate
Veterinary (miscellaneous)
030231 tropical medicine
Bendiocarb
Mosquito Vectors
Biology
DDT
03 medical and health sciences
parasitic diseases
Anopheles
Burkina Faso
medicine
Animals
Pesticide
medicine.disease
biology.organism_classification
Vector control
Maladie transmise par vecteur
Malaria
Deltamethrin
chemistry
Insect Science
Mutation
Parasitology
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
Zdroj: Acta Tropica
Acta Tropica, Elsevier, 2019, 197, pp.105054. ⟨10.1016/j.actatropica.2019.105054⟩
ISSN: 1873-6254
0001-706X
Popis: International audience; Vector control constitutes a fundamental approach in reducing vector density and the efficient option to break malaria transmission in Africa. Malaria vectors developed resistance to almost all classes of insecticides recommended by WHO for vector control in most places of African countries and may compromise the vector control strategies. This study updated the resistance status of Anopheles gambiae complex populations to insecticides recommended for vector control in the western part of Burkina Faso. Insecticide susceptibility bioassays were performed on seven natural populations of An. gambiae complex from western Burkina Faso in the 2016 rainy season using the WHO protocol. Biochemical assays were carried out according to the WHO protocol on the same populations to estimate detoxifying enzymes activities including non-specific esterases (NSEs), oxidases (cytochrome P450) and Glutathione-S-Transferases (GSTs). Polymerase Chain Reactions (PCRs) were performed for the identification of the An. gambiae complex species as well as the detection of kdr-west and ace-1 mutations. Susceptibility bioassays showed that An. gambiae complex was multi-resistant to pyrethroids, DDT and carbamates in almost all areas. The mortality rates ranged from 10 to 38%, 2.67 to 59.57% and 64.38 to 98.02% for Deltamethrin, DDT and Bendiocarb respectively. A full susceptibility (100%) to an organophosphate, the Chlorpyrifos-methyl, was observed at the different sites. Three (3) species of the An. gambiae complex were identified: An. gambiae s.s, An. coluzzii and An. arabiensis. The frequencies of the kdr-w mutation were highly widespread (0.66 to 0.98) among the three species of the complex. The ace-1 mutation was detected at low frequencies (0 to 0.12) in An. gambiae s.s and An. coluzzii. A high level of GSTs and NSEs were observed within the different populations of the An. gambiae complex. Several mechanisms of insecticide resistance were found simultaneously in the same populations of An. gambiae complex conferring high multi-resistance to DDT, Carbamate and Pyrethroids. The full susceptibility of An. gambiae complex to organophosphates is a useful data for the national malaria control program in selecting the most appropriate products to both maintain the effectiveness of vector control strategies and best manage insecticide resistance as well as developing new alternative strategies for the control of major malaria vectors in Burkina Faso.
Databáze: OpenAIRE
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