Synthesis of selenoglycosides and selenium linked disaccharides using reductive cleavage of diselenides

Autor:	Pradip Shit, Samim Sahaji, Anup Kumar Misra
Rok vydání:	2022
Předmět:	Selenium Organic Chemistry General Medicine Glycosides Disaccharides Biochemistry Analytical Chemistry
Zdroj:	Carbohydrate research. 516
ISSN:	1873-426X
Popis:	Reduction of diselenides using a combination of hydrazine monohydrate and potassium hydroxide (KOH) followed by the treatment of the selenolate ions generated in situ with glycosyl halides under a one-pot, two-step phase transfer reaction condition resulted in the formation of beta-selenoglycosides in excellent yield. In addition, selenium linked disaccharide derivatives with beta-glycosidic linkages were also prepared by the reductive cleavage of diglycosyl diselenide derivatives in very good yield. The reaction condition is non-hazardous and high yielding for scaling up.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d50fc084b39a99a5fa3bacff2279b4 https://pubmed.ncbi.nlm.nih.gov/35461049 Zobrazit plný text záznamu Full Text from ScienceDirect