Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder
| Autor: | Ashley N. Sutherland, Hauke Bartsch, Rebecca J. Theilmann, Lisa T. Eyler, Benjamin S. McKenna, Tanya T. Nguyen, Sheena I. Dev |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Gerontology Aging medicine.medical_specialty Bipolar Disorder Trail Making Test Audiology White matter 03 medical and health sciences Cognition 0302 clinical medicine Fractional anisotropy medicine Humans Cingulum (brain) Bipolar disorder Aged Brain Middle Aged medicine.disease White Matter White matter microstructure 030227 psychiatry Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure Case-Control Studies Anisotropy Female Geriatrics and Gerontology Psychology 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | The American Journal of Geriatric Psychiatry. 25:744-752 |
| ISSN: | 1064-7481 |
| Popis: | Objectives Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging. Design Cross-sectional study. Setting University of California San Diego and the Veterans Administration San Diego Healthcare System. Participants 33 euthymic BD and 38 HC participants. Measurements Diffusion tensor imaging was acquired as a measure of WM integrity, and tract-specific fractional anisotropy (FA) was extracted utilizing the Johns Hopkins University probability atlas. PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test. Results BD participants demonstrated slower PS compared with the HC group, but no group differences were found in FA across tracts. Multiple linear regressions revealed a significant group-by-age interaction for the right uncinate fasciculus, the left hippocampal portion of the cingulum, and for PS, such that older age was associated with lower FA values and slower PS in the BD group only. The relationship between age and PS did not significantly change after accounting for uncinate FA, suggesting that the observed age associations occur independently. Conclusions Results provide support for future study of the accelerated aging hypothesis by identifying markers of brain health that demonstrate a differential age association in BD. |
| Databáze: | OpenAIRE |
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